Gieling Elise T, Schuurman Teun, Nordquist Rebecca E, van der Staay F Josef
Program 'Emotion and Cognition', Department of Farm Animal Health, Veterinary Faculty, Utrecht University, 80166, Utrecht, 3508 TD, The Netherlands.
Curr Top Behav Neurosci. 2011;7:359-83. doi: 10.1007/7854_2010_112.
In experimental animal research, a short phylogenetic distance, i.e., high resemblance between the model species and the species to be modeled is expected to increase the relevance and generalizability of results obtained in the model species. The (mini)pig shows multiple advantageous characteristics that have led to an increase in the use of this species in studies modeling human medical issues, including neurobehavioral (dys)functions. For example, the cerebral cortex of pigs, unlike that of mice or rats, has cerebral convolutions (gyri and sulci) similar to the human neocortex. We expect that appropriately chosen pig models will yield results of high translational value. However, this claim still needs to be substantiated by research, and the area of pig research is still in its infancy. This chapter provides an overview of the pig as a model species for studying cognitive dysfunctions and neurobehavioral disorders and their treatment, along with a discussion of the pros and cons of various tests, as an aid to researchers considering the use of pigs as model animal species in biomedical research.
在实验动物研究中，人们期望系统发育距离短，即模型物种与待建模物种之间的高度相似性，能够提高在模型物种中获得的结果的相关性和可推广性。（小型）猪具有多种优势特征，这使得该物种在模拟人类医学问题（包括神经行为（功能）障碍）的研究中的使用有所增加。例如，与小鼠或大鼠不同，猪的大脑皮层具有与人类新皮层相似的脑回（脑回和脑沟）。我们预计，适当选择的猪模型将产生具有高转化价值的结果。然而，这一说法仍需通过研究来证实，并且猪研究领域仍处于起步阶段。本章概述了猪作为研究认知功能障碍和神经行为障碍及其治疗的模型物种，同时讨论了各种测试的优缺点，以帮助考虑在生物医学研究中使用猪作为模型动物物种的研究人员。
