RNA 世界的药物基因组学：药物治疗中的结构 RNA 多态性。
Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.
机构信息
Program in Pharmacogenomics, Department of Pharmacology, The Ohio State University College of Medicine, Columbus, Ohio, USA.
出版信息
Clin Pharmacol Ther. 2011 Mar;89(3):355-65. doi: 10.1038/clpt.2010.314. Epub 2011 Feb 2.
Abstract
The use of pharmacogenomic biomarkers can enhance treatment outcomes. Regulatory polymorphisms are promising biomarkers that have proven difficult to uncover. They come in two flavors: those that affect transcription (regulatory single-nucleotide polymorphisms (rSNPs)) and those that affect RNA functions such as splicing, turnover, and translation (termed structural RNA SNPs (srSNPs)). This review focuses on the role of srSNPs in drug metabolism, transport, and response. An understanding of the nature and diversity of srSNPs and rSNPs enables clinical scientists to evaluate genetic biomarkers.
摘要
药物基因组学生物标志物的应用可以提高治疗效果。调控多态性是很有前途的生物标志物，但很难发现。它们有两种类型：影响转录的（调控单核苷酸多态性（rSNP））和影响 RNA 功能，如剪接、周转和翻译的（称为结构 RNA SNP（srSNP））。本文重点介绍了 srSNP 在药物代谢、转运和反应中的作用。了解 srSNP 和 rSNP 的性质和多样性使临床科学家能够评估遗传生物标志物。
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