The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Emerg Infect Dis. 2011 Feb;17(2):209-14. doi: 10.3201/eid1702.100718.
Human penicilliosis marneffei is an emerging infectious disease caused by the fungus Penicillium marneffei. High prevalence of infection among bamboo rats of the genera Rhizomys and Cannomys suggest that these rodents are a key facet of the P. marneffei life cycle. We trapped bamboo rats during June 2004-July 2005 across Guangxi Province, China, and demonstrated 100% prevalence of infection. Multilocus genotypes show that P. marneffei isolates from humans are similar to those infecting rats and are in some cases identical. Comparison of our dataset with genotypes recovered from sites across Southeast Asia shows that the overriding component of genetic structure in P. marneffei is spatial, with humans containing a greater diversity of genotypes than rodents. Humans and bamboo rats are sampling an as-yet undiscovered common reservoir of infection, or bamboo rats are a vector for human infections by acting as amplifiers of infectious dispersal stages.
人类马尔尼菲青霉病是一种由马尔尼菲青霉菌引起的新发传染病。在 Rhizomys 和 Cannomys 属的竹鼠中，感染率很高，这表明这些啮齿动物是青霉菌生命周期的一个关键方面。我们在 2004 年 6 月至 2005 年 7 月期间在中国广西捕获了竹鼠，并证明了感染率为 100%。多位点基因型表明，从人类分离到的青霉菌与感染大鼠的青霉菌相似，在某些情况下是相同的。将我们的数据集与从东南亚各地采集的基因型进行比较表明，在青霉菌中，遗传结构的主要组成部分是空间，人类比啮齿动物包含更多的基因型。人类和竹鼠正在采样一个尚未发现的共同感染源，或者竹鼠作为传染性扩散阶段的传播媒介，导致人类感染。
