Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Emerg Infect Dis. 2011 Feb;17(2):255-7. doi: 10.3201/eid1702.101724.
During April 2009-June 2010, thirty-seven (0.5%) of 6,740 pandemic (H1N1) 2009 viruses submitted to a US surveillance system were oseltamivir resistant. Most patients with oseltamivir-resistant infections were severely immunocompromised (76%) and had received oseltamivir before specimen collection (89%). No evidence was found for community circulation of resistant viruses; only 4 (unlinked) patients had no oseltamivir exposure.
在 2009 年 4 月至 2010 年 6 月期间,向美国监测系统提交的 6740 株大流行(H1N1)2009 病毒中,有 37 株(0.5%)对奥司他韦耐药。大多数对奥司他韦耐药的感染患者严重免疫功能低下(76%),且在采集标本前使用过奥司他韦(89%)。没有发现耐药病毒在社区中传播的证据;只有 4 名(无关联)患者没有奥司他韦接触史。