生物标志物N端前脑钠肽与肝脏疾病

The biomarker N-terminal pro-brain natriuretic peptide and liver diseases.

作者信息

Wang Ling, Geng Jiabao, Li Jie, Li Tong, Matsumori Akira, Chang Yibin, Lu Fengmin, Zhuang Hui

机构信息

Department of Microbiology, Peking University Health Science Center, China.

出版信息

Clin Invest Med. 2011 Feb 1;34(1):E30-7. doi: 10.25011/cim.v34i1.14910.

DOI:10.25011/cim.v34i1.14910

PMID:21291633

Abstract

PURPOSE

NT-proBNP has emerged as a powerful diagnostic and prognostic biomarker in heart disease. Studies showed that NT-proBNP is a sensitive biomarker for identifying patients with heart failure caused by hepatitis C virus (HCV) related myocarditis. The purpose of this study was to evaluate the correlation between the serum concentration of NT-proBNP and hepatitis virus infection/liver disease.

METHODS

223 serum samples from blood donors (aged 19~50 years old) were collected as a control group, and 644 samples were obtained from patients infected by hepatitis viruses including 493 HBV: 364 chronic hepatitis (CH), 86 hepatocellular carcinoma (HCC) and 43 liver cirrhosis (LC) and 151 HCV (85 CH, 14 HCC, 52 LC). All samples were assayed with an Elecsys immunoassay analyzer for NT-proBNP concentration.

RESULTS

The mean concentration of NT-proBNP in the control group was 21.77 pg/ml and showed no significant variation with either age or gender. Both the mean value and the rate of abnormality of NT-proBNP were significantly higher for the HBV- and HCV-infected groups in comparison with the control group. The mean NT-proBNP value (380.24 pg/ml) and abnormality rate (38.41%) in the HCV group were higher than that of the HBV group. For samples from patients with HBV/HCV-related hepatic disease/pathology, the mean NT-proBNP value (517.19 pg/ml/597.18 pg/ml) were the highest in the liver cirrhosis group.

CONCLUSIONS

Hepatic pathologic lesions, particularly cirrhosis, may contribute to the elevation of NT-proBNP in subjects with HBV/HCV infection.

摘要

目的

N末端脑钠肽前体（NT-proBNP）已成为心脏病诊断和预后评估的重要生物标志物。研究表明，NT-proBNP是识别丙型肝炎病毒（HCV）相关性心肌炎所致心力衰竭患者的敏感生物标志物。本研究旨在评估血清NT-proBNP浓度与肝炎病毒感染/肝脏疾病之间的相关性。

方法

收集223份来自献血者（年龄19至50岁）的血清样本作为对照组，从感染肝炎病毒的患者中获取644份样本，其中包括493例乙肝病毒（HBV）感染者：364例慢性肝炎（CH）、86例肝细胞癌（HCC）和43例肝硬化（LC），以及151例丙肝病毒（HCV）感染者（85例CH、14例HCC、52例LC）。所有样本均使用罗氏电化学发光免疫分析仪检测NT-proBNP浓度。

结果

对照组NT-proBNP的平均浓度为21.77 pg/ml，且在年龄和性别方面均无显著差异。与对照组相比，HBV和HCV感染组的NT-proBNP平均值和异常率均显著更高。HCV组的NT-proBNP平均值（380.24 pg/ml）和异常率（38.41%）高于HBV组。对于HBV/HCV相关肝病/病理患者的样本，肝硬化组的NT-proBNP平均值最高（分别为517.19 pg/ml/597.18 pg/ml）。