National Nutrition Institute, Cairo, Egypt.
J Clin Lipidol. 2009 Aug;3(4):269-74. doi: 10.1016/j.jacl.2009.07.002. Epub 2009 Jul 14.
Adipose tissue is known to produce and secrete a variety of bioactive substances known as adipocytokines. Adiponectin and leptin are considered to be among the most important adipocytokines:
We sought to explore the relationships between adipocytokines (adiponectin and leptin), plasma lipoprotein lipid, and diabetic control indices in type 1 diabetic subjects.
In this study 63 clinically diagnosed type 1 diabetic subjects and 30 age- and sex-matched healthy control subjects were analyzed. Age, sex, diabetic duration, family history of diabetes, daily insulin dose, weight, height, body mass index, and systolic and diastolic blood pressure were recorded. Fasting blood glucose, glycated hemoglobin A(1c), total hemoglobin, plasma lipoprotein, lipid and plasma concentrations of adiponectin and leptin were measured in type 1 diabetic subjects and control subjects.
In this study a significant increase in triglycerides and high-density lipoprotein cholesterol in plasma of type 1 diabetics was found as compared with normal control subjects. In type 1diabetic subjects, plasma adiponectin was significantly elevated, whereas leptin showed a significant decrease as compared to a normal control group. Leptin concentrations showed a positive correlation with body mass index and systolic blood pressure but a negative correlation with both fasting blood glucose and glycated hemoglobinA(1c).
The results of this study suggest that blood leptin but not adiponectin concentrations have a significant correlation with indices of glycemic control.
脂肪组织已知会产生和分泌各种生物活性物质，称为脂肪细胞因子。脂联素和瘦素被认为是最重要的脂肪细胞因子之一：
我们试图探讨脂肪细胞因子（脂联素和瘦素）、血浆脂蛋白脂质与 1 型糖尿病患者的糖尿病控制指标之间的关系。
本研究分析了 63 例临床诊断为 1 型糖尿病的患者和 30 名年龄和性别匹配的健康对照者。记录年龄、性别、糖尿病病程、糖尿病家族史、每日胰岛素剂量、体重、身高、体重指数以及收缩压和舒张压。测量 1 型糖尿病患者和对照组的空腹血糖、糖化血红蛋白 A(1c)、总血红蛋白、血浆脂蛋白、血脂和血浆脂联素和瘦素浓度。
与正常对照组相比，1 型糖尿病患者的血浆甘油三酯和高密度脂蛋白胆固醇明显升高。与正常对照组相比，1 型糖尿病患者的血浆脂联素明显升高，而瘦素明显降低。瘦素浓度与体重指数和收缩压呈正相关，与空腹血糖和糖化血红蛋白 A(1c)呈负相关。
本研究结果表明，血瘦素而不是脂联素浓度与血糖控制指标有显著相关性。
