人胎盘在体内对四种非代谢亲水分子的通透性。
Permeability of the human placenta in vivo to four non-metabolized hydrophilic molecules.
作者信息
Bain M D, Copas D K, Taylor A, Landon M J, Stacey T E
机构信息
Clinical Research Centre, Harrow.
出版信息
J Physiol. 1990 Dec;431:505-13. doi: 10.1113/jphysiol.1990.sp018343.
Abstract
- Permeability of the human placenta to four permeants of different molecular size was measured at Caesarean section in seven normal full-term pregnancies. 2. Placental clearance for mannitol was 8.7 +/- 1.1 ml min-1 (mean +/- S.E.M.), lactulose 6.3 +/- 0.8, chromium ethylenediaminetetraacetic acid (CrEDTA) 3.7 +/- 0.5, and inulin 0.98 +/- 0.1. 3. The permeability data were analysed in terms of restricted diffusion through 'notional' water-filled pores and found to be incompatible with a single population of uniform pores.
摘要
- 在七例正常足月妊娠的剖宫产手术中，测量了人胎盘对四种不同分子大小渗透物的通透性。2. 甘露醇的胎盘清除率为8.7±1.1毫升/分钟（平均值±标准误），乳果糖为6.3±0.8，乙二胺四乙酸铬（CrEDTA）为3.7±0.5，菊粉为0.98±0.1。3. 根据通过“假想”充满水的孔隙的受限扩散对通透性数据进行分析，发现其与单一均匀孔隙群体不相符。
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本文引用的文献
1
A new method for the determination of inulin in plasma and urine.一种测定血浆和尿液中菊粉的新方法。
Clin Chim Acta. 1956 Sep-Oct;1(5):470-4. doi: 10.1016/0009-8981(56)90020-1.
2
Volumes of distribution of sodium and albumin in the sheep placenta.绵羊胎盘钠和白蛋白的分布容积
J Physiol. 1983 Mar;336:13-26. doi: 10.1113/jphysiol.1983.sp014562.
3
Transport of polar non-electrolytes across the intact and perfused guinea-pig placenta.极性非电解质在完整和灌注的豚鼠胎盘内的转运。
Placenta. 1980 Oct-Dec;1(4):277-85. doi: 10.1016/s0143-4004(80)80029-4.
4
Estimation of the equivalent pore dimensions in the rabbit placenta.兔胎盘等效孔径的估算
Life Sci. 1969 Feb 1;8(3):167-80. doi: 10.1016/0024-3205(69)90091-5.
5
Permeability of rabbit placenta to large molecules.兔胎盘对大分子的通透性。
Am J Physiol. 1971 Mar;220(3):688-93. doi: 10.1152/ajplegacy.1971.220.3.688.
6
Permeability of lung capillaries and alveoli to non-electrolytes in the foetal lamb.胎羊肺毛细血管和肺泡对非电解质的通透性
J Physiol. 1971 Dec;219(2):303-30. doi: 10.1113/jphysiol.1971.sp009663.
7
Maternal-fetal urea concentration difference in man: metabolic significance.人类母胎尿素浓度差异：代谢意义
J Pediatr. 1971 Nov;79(5):809-11. doi: 10.1016/s0022-3476(71)80396-7.
8
The antenatal measurement of fetal urine production.
J Obstet Gynaecol Br Commonw. 1973 Aug;80(8):680-6. doi: 10.1111/j.1471-0528.1973.tb16049.x.
9
The turnover of amniotic fluid protein in the human conceptus.
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10
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