人胎盘对菊粉和甘露醇的体内通透性。
In vivo permeability of the human placenta to inulin and mannitol.
作者信息
Bain M D, Copas D K, Landon M J, Stacey T E
机构信息
Section of Perinatal and Child Health, Clinical Research Centre, Harrow.
出版信息
J Physiol. 1988 May;399:313-9. doi: 10.1113/jphysiol.1988.sp017082.
Abstract
- Permeability of the term human placenta to inulin and mannitol was measured in six normal pregnancies. 2. Bolus and continuous infusion of inulin and mannitol to the mother for 1-2 h before delivery by Caesarean section achieved steady-state maternal serum concentrations. Net accumulation of inulin and mannitol in the fetus was measured by the subsequent neonatal urinary excretion. 3. Transplacental clearance was calculated by dividing the net flux by the time-averaged transplacental concentration gradient. Clearance for inulin was 0.86 +/- 0.1 ml min-1 (mean +/- S.E.M.) and for mannitol 7.3 +/- 0.8 ml min-1 (n = 6 in both cases).
摘要
- 在六例正常妊娠中测量了足月人胎盘对菊粉和甘露醇的通透性。2. 在剖宫产分娩前1 - 2小时，对母亲进行菊粉和甘露醇的推注及持续输注，以达到稳定状态的母体血清浓度。通过随后新生儿的尿液排泄来测量胎儿体内菊粉和甘露醇的净蓄积量。3. 经胎盘清除率通过净通量除以时间平均经胎盘浓度梯度来计算。菊粉的清除率为0.86±0.1毫升/分钟（平均值±标准误），甘露醇的清除率为7.3±0.8毫升/分钟（两种情况均为n = 6）。
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本文引用的文献
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