First Department of Comprehensive Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, 1-847 Amanuma, Omiya, Saitama 330-8503, Japan.
Diabetes Res Clin Pract. 2011 May;92(2):181-6. doi: 10.1016/j.diabres.2011.01.009. Epub 2011 Feb 2.
We aimed to examine whether circulating levels of osteocalcin, bone formation marker secreted from osteoblast, are changed in glucose-intolerant subjects without taking glucose lowering agent, because bone metabolism is reportedly related to glucose metabolism in animal and human studies. According to 75 g oral glucose tolerance test (75 g-OGTT), all subjects (47.6 ± 10.2 years of age; 45 men and 10 women) were divided into three categories: normal glucose tolerance (NGT, n = 39), prediabetes (PDM, n = 11) that included impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and diabetes (T2DM, n = 5). Serum osteocalcin levels were increased in T2DM as compared to NGT. In all the participants, simple regression analysis model revealed positive correlation of osteocalcin with plasma glucose at 120 min, G(120), on 75 g-OGTT, negative with both creatinine and Ln(CRP), but not significantly with fasting plasma glucose. Osteocalcin and leptin were independent variables for G(120) (P = 0.026 and 0.035, respectively). In multinomial logistic analysis leptin (PDM vs. NGT: P = 0.02 Odds ratio (OR) of 1.05, 95% confidence intervals, 1.007-1.084) and osteocalcin (T2DM vs. NGT: P = 0.038, OR 10.8, 1.13-102.4) were independently associated. We conclude that circulating osteocalcin and leptin are related to glucose intolerant state.
我们旨在研究葡萄糖耐量受损（但未服用降血糖药物）患者的循环骨钙素（成骨细胞分泌的骨形成标志物）水平是否发生变化，因为动物和人体研究均表明，骨代谢与葡萄糖代谢有关。根据 75g 口服葡萄糖耐量试验（75g-OGTT），将所有受试者（年龄 47.6±10.2 岁；男 45 例，女 10 例）分为三组：正常糖耐量（NGT，n=39）、包括空腹血糖受损（IFG）和糖耐量受损（IGT）的糖尿病前期（PDM，n=11）和 2 型糖尿病（T2DM，n=5）。与 NGT 相比，T2DM 患者的血清骨钙素水平升高。在所有参与者中，简单回归分析模型显示，75g-OGTT 时 120 分钟时的血糖（G120）与骨钙素呈正相关，与肌酐和 Ln（CRP）呈负相关，但与空腹血糖无显著相关性。骨钙素和瘦素是 G120 的独立变量（P=0.026 和 0.035）。在多项逻辑回归分析中，瘦素（PDM 与 NGT：P=0.02，OR 为 1.05，95%置信区间，1.007-1.084）和骨钙素（T2DM 与 NGT：P=0.038，OR 为 10.8，1.13-102.4）与葡萄糖耐量受损状态独立相关。我们的结论是，循环骨钙素和瘦素与葡萄糖不耐受状态有关。
