Department of Medicine, Kyung Hee University, Seoul, Korea.
Diabetes Care. 2012 Sep;35(9):1919-24. doi: 10.2337/dc11-2471. Epub 2012 Jul 6.
Recent human studies suggested that serum osteocalcin is associated with the cross-talk between bone and energy metabolism. The aim of this study was to determine whether serum osteocalcin level is independently associated with the development of type 2 diabetes.
A retrospective cohort study was performed of 1,229 nondiabetic men, aged 25-60 years, who were recruited from the Health Promotion Center, Samsung Medical Center, between January 1997 and December 1997. They were followed regularly at the center on an out-patient basis and during hospitalization for a mean of 8.4 years, and the development of type 2 diabetes was determined.
In the baseline analysis, BMI, body fat percentage, triglyceride, homeostasis model assessment of insulin resistance value, and plasminogen activator inhibitor-1 levels varied inversely with the osteocalcin tertiles, and serum high-density lipoprotein cholesterol levels increased with the osteocalcin tertiles. However, no differences were observed in fasting glucose and glycated hemoglobin levels across the osteocalcin tertiles. Incident type 2 diabetes occurred in 90 (7.3%) of the study subjects. In Cox proportional hazards models, however, no statistical differences in the development of type 2 diabetes across the osteocalcin tertiles were evident after adjustment of other risk factors for incident diabetes.
Despite baseline associations with favorable metabolic parameters, the serum osteocalcin level was not associated with the development of type 2 diabetes in middle-aged males.
最近的人体研究表明，血清骨钙素与骨骼和能量代谢之间的相互作用有关。本研究旨在确定血清骨钙素水平是否与 2 型糖尿病的发生独立相关。
对 1997 年 1 月至 1997 年 12 月期间在三星医疗中心健康促进中心招募的 1229 名年龄在 25-60 岁之间的非糖尿病男性进行了回顾性队列研究。他们在中心定期进行门诊和住院随访，平均随访时间为 8.4 年，并确定了 2 型糖尿病的发生情况。
在基线分析中，BMI、体脂百分比、甘油三酯、胰岛素抵抗评估的稳态模型、纤溶酶原激活物抑制剂-1 水平与骨钙素三分位呈负相关，而血清高密度脂蛋白胆固醇水平随骨钙素三分位增加而增加。然而，骨钙素三分位之间空腹血糖和糖化血红蛋白水平没有差异。在研究对象中，有 90 例（7.3%）发生了 2 型糖尿病。然而，在 Cox 比例风险模型中，在调整了其他糖尿病发病风险因素后，骨钙素三分位之间 2 型糖尿病的发展没有统计学差异。
尽管与有利的代谢参数有基线关联，但血清骨钙素水平与中年男性 2 型糖尿病的发生无关。
