National Institute for Health and Welfare, Oulu, Finland.
Ann Oncol. 2011 Aug;22(8):1916-21. doi: 10.1093/annonc/mdq694. Epub 2011 Feb 3.
Evidence suggests that inflammation may be associated with increased risk of ovarian cancer but there is paucity of studies investigating this association, especially using over-time changes in inflammatory biomarkers.
We conducted a prospective population-based case-control study nested within the Finnish Maternity Cohort (FMC). Within the FMC, 170 women with ovarian cancer who had donated serum samples to the cohort twice, ≥1 year apart, before cancer diagnoses were identified. One control per case was matched for age, parity and sampling date.
Comparing the highest with lowest tertiles, the odds ratio (OR) of ovarian cancer using the first set of serum samples (mean lag time to cancer diagnosis 9.0 years) was 1.62 [95% confidence interval (CI) 0.93-2.83]. However, analysis conducted using the second set of serum samples donated closer to cancer diagnosis (mean lag time 6.4 years) revealed a significantly increased risk of ovarian cancer comparing extreme tertiles of C-reactive protein (CRP) concentrations; OR 1.96 (95% CI 1.11-3.4). Over time, increases in individuals' CRP concentrations were also associated with increased risk; OR 1.90 (95% CI 1.12-3.23).
The results suggest that inflammation may precede ovarian cancer since increasing CRP concentrations, both across tertiles and longitudinally at the individual level, were associated with increased risk.
有证据表明，炎症可能与卵巢癌风险增加有关，但目前研究炎症标志物随时间变化与该关联的研究较少。
我们开展了一项前瞻性基于人群的病例对照研究，该研究嵌套在芬兰母婴队列（FMC）中。在 FMC 中，确定了 170 名曾两次向队列捐赠血清样本、两次间隔时间≥ 1 年且在癌症诊断之前的卵巢癌患者。每例病例匹配 1 名年龄、产次和采样日期与之相同的对照。
使用第一组血清样本（癌症诊断前平均滞后时间为 9.0 年）比较最高和最低三分位数时，卵巢癌的优势比（OR）为 1.62 [95%置信区间（CI）为 0.93-2.83]。然而，使用更接近癌症诊断时捐赠的第二组血清样本进行的分析显示，C 反应蛋白（CRP）浓度的极端三分位数比较时，卵巢癌的风险显著增加；OR 为 1.96（95% CI 为 1.11-3.4）。随着时间的推移，个体 CRP 浓度的增加也与风险增加相关；OR 为 1.90（95% CI 为 1.12-3.23）。
研究结果表明，炎症可能先于卵巢癌发生，因为 CRP 浓度在三分位数和个体水平上的纵向增加均与风险增加相关。
