Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
Am J Trop Med Hyg. 2011 Feb;84(2):192-9. doi: 10.4269/ajtmh.2011.10-0363.
In resource-constrained environments, monitoring the occurrence of tuberculosis (TB), human immunodeficiency virus (HIV), or malaria resistant to the limited number of available drugs is essential for national treatment program success. Countries with limited resources and technical capacity rely on survey designs and methods that are simple and easily integrated into routine clinical activities to minimize the impact on overburdened clinics. This paper reviews the most commonly used methods for drug-resistance surveillance of TB, HIV, and malaria and discusses the strengths and limitations of these different strategies.
在资源有限的环境中，监测结核病（TB）、人类免疫缺陷病毒（HIV）或疟疾对现有有限数量药物的耐药性的发生对于国家治疗计划的成功至关重要。资源有限和技术能力有限的国家依赖于设计简单且易于纳入常规临床活动的调查设计和方法，以最大程度地减少对负担过重的诊所的影响。本文综述了用于 TB、HIV 和疟疾耐药性监测的最常用方法，并讨论了这些不同策略的优缺点。
