Department of Parasitology, Kangwon National University College of Medicine, Chuncheon, Gangwon-do, Republic of Korea.
Am J Trop Med Hyg. 2011 Feb;84(2):292-7. doi: 10.4269/ajtmh.2011.10-0432.
Plasmodium vivax msp1p, a paralog of the candidate vaccine antigen P. vivax merozoite surface protein 1, possesses a signal peptide at its N-terminus and two epidermal growth factor-like domains at its C-terminus with a glycosylphosphatidylinositol attachment site. The msp1p gene locus may have originated by a duplication of the msp1 gene locus in a common ancestor of the analyzed Plasmodium species and lost from P. yoelii, P. berghei, and P. falciparum during their evolutionary history. Full-length sequences of the msp1p gene were generally highly conserved; they had a few amino acid substitutions, one highly polymorphic E/Q-rich region, and a single-to-triple hepta-peptide repeat motif. Twenty-one distinguishable allelic types (A1-A21) of the E/Q-rich region were identified from worldwide isolates. Among them, four types were detected in isolates from South Korea. The length polymorphism of the E/Q-rich region might be useful as a genetic marker for population structure studies in malaria-endemic areas.
恶性疟原虫 msp1p，候选疫苗抗原恶性疟原虫裂殖子表面蛋白 1 的一个旁系同源物，在其 N 端具有信号肽，在其 C 端具有两个表皮生长因子样结构域和一个糖基磷脂酰肌醇附着位点。msp1p 基因座可能是由分析的疟原虫种的共同祖先中的 msp1 基因座重复产生的，并在其进化历史中从约氏疟原虫、伯氏疟原虫和恶性疟原虫丢失。全长 msp1p 基因序列通常高度保守；它们有一些氨基酸取代，一个高度多态的 E/Q 丰富区，以及一个单一到七肽重复基序。从世界范围内的分离株中鉴定出 21 种可区分的等位基因类型（A1-A21）。其中，在来自韩国的分离株中检测到四种类型。E/Q 丰富区的长度多态性可能可作为疟疾流行地区种群结构研究的遗传标记。
