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Shape-shifting and tumor suppression by PLZF.

作者信息

Hobbs Robin M, Pandolfi Pier Paolo

机构信息

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Oncotarget. 2010 May;1(1):3-5. doi: 10.18632/oncotarget.102.

DOI:10.18632/oncotarget.102
PMID:21293049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4053541/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a979/4053541/b5faa55d8d9e/oncotarget-01-003-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a979/4053541/b5faa55d8d9e/oncotarget-01-003-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a979/4053541/b5faa55d8d9e/oncotarget-01-003-g001.jpg

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Understanding PLZF: two transcriptional targets, REDD1 and smooth muscle α-actin, define new questions in growth control, senescence, self-renewal and tumor suppression.了解 PLZF:两个转录靶标,REDD1 和平滑肌 α-肌动蛋白,为生长控制、衰老、自我更新和肿瘤抑制中的新问题提供了定义。
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本文引用的文献

1
PLZF is a regulator of homeostatic and cytokine-induced myeloid development.PLZF是稳态和细胞因子诱导的髓系发育的调节因子。
Genes Dev. 2009 Sep 1;23(17):2076-87. doi: 10.1101/gad.1788109.
2
Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein.早幼粒细胞白血病锌指蛋白对Myc的翻译后调控
Int J Cancer. 2009 Oct 1;125(7):1558-65. doi: 10.1002/ijc.24449.
3
EMT, the cytoskeleton, and cancer cell invasion.上皮-间质转化、细胞骨架与癌细胞侵袭
早幼粒细胞白血病锌指转录因子对人子宫内膜基质细胞蜕膜化至关重要。
PLoS Genet. 2016 Apr 1;12(4):e1005937. doi: 10.1371/journal.pgen.1005937. eCollection 2016 Apr.
4
Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) gene repression.早幼粒细胞白血病锌指蛋白(PLZF)在细胞增殖及细胞周期蛋白依赖性激酶抑制剂1A(p21WAF/CDKN1A)基因抑制中的作用。
J Biol Chem. 2014 Jul 4;289(27):18625-40. doi: 10.1074/jbc.M113.538751. Epub 2014 May 12.
5
Recent progress in targeting cancer.癌症靶向治疗的最新进展。
Aging (Albany NY). 2011 Dec;3(12):1154-62. doi: 10.18632/aging.100421.
6
Understanding PLZF: two transcriptional targets, REDD1 and smooth muscle α-actin, define new questions in growth control, senescence, self-renewal and tumor suppression.了解 PLZF:两个转录靶标,REDD1 和平滑肌 α-肌动蛋白,为生长控制、衰老、自我更新和肿瘤抑制中的新问题提供了定义。
Cell Cycle. 2011 Mar 1;10(5):771-5. doi: 10.4161/cc.10.5.14829.
Cancer Metastasis Rev. 2009 Jun;28(1-2):15-33. doi: 10.1007/s10555-008-9169-0.
4
The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms.早幼粒细胞白血病锌指蛋白-微小RNA-221/-222通路通过多种致癌机制控制黑色素瘤进展。
Cancer Res. 2008 Apr 15;68(8):2745-54. doi: 10.1158/0008-5472.CAN-07-2538.
5
RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.维甲酸受体α-早幼粒细胞白血病锌指蛋白克服了早幼粒细胞白血病锌指蛋白介导的对细胞视黄酸结合蛋白I的抑制作用,导致11号与17号染色体易位的急性早幼粒细胞白血病出现维甲酸耐药。
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18694-9. doi: 10.1073/pnas.0704433104. Epub 2007 Nov 13.
6
POZ for effect--POZ-ZF transcription factors in cancer and development.POZ 的作用——癌症与发育过程中的POZ-ZF转录因子
Trends Cell Biol. 2006 Nov;16(11):578-87. doi: 10.1016/j.tcb.2006.09.003. Epub 2006 Sep 22.
7
Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression.前B细胞白血病转录因子1是早幼粒细胞白血病锌指蛋白介导的黑色素瘤细胞生长抑制的主要靶点。
Oncogene. 2007 Jan 18;26(3):339-48. doi: 10.1038/sj.onc.1209800. Epub 2006 Jul 24.
8
PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation.早幼粒细胞白血病锌指蛋白调控前B细胞白血病转录因子1的转录,且前B细胞白血病转录因子1-同源盒基因C8复合物导致雄激素非依赖性前列腺癌增殖。
Prostate. 2006 Jul 1;66(10):1092-9. doi: 10.1002/pros.20443.
9
Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis.小鼠中PLZP的破坏导致T淋巴细胞增殖增加、细胞因子产生以及造血干细胞稳态改变。
Mol Cell Biol. 2004 Dec;24(23):10456-69. doi: 10.1128/MCB.24.23.10456-10469.2004.
10
Essential role of Plzf in maintenance of spermatogonial stem cells.PLZF在精原干细胞维持中的重要作用。
Nat Genet. 2004 Jun;36(6):653-9. doi: 10.1038/ng1367. Epub 2004 May 23.