Department of Chemistry, Clemson University, Clemson, South Carolina 29634, USA.
Nanoscale. 2011 Apr;3(4):1451-5. doi: 10.1039/c0nr00834f. Epub 2011 Feb 3.
We report a novel nanoparticle that is promising for photodynamic therapy applications, which consists of a π-conjugated polymer doped with a singlet oxygen photosensitizer. The nanoparticles exhibit highly efficient collection of excitation light due to the large excitation cross-section of the polymer. A quantum efficiency of singlet oxygen production of 0.5 was determined. Extraordinarily large two-photon excitation cross-sections were determined, indicating promise for near infrared multiphoton photodynamic therapy. Gel electrophoresis of DNA after near-UV irradiation in the presence of nanoparticles indicated both purine base and backbone DNA damage.
我们报告了一种新型的纳米粒子，它在光动力疗法的应用中很有前景，由掺杂了单线态氧敏化剂的π共轭聚合物组成。由于聚合物的大激发截面，纳米粒子表现出高效的激发光收集。测定了单线态氧产生的量子效率为 0.5。还测定了非常大的双光子激发截面，这表明该纳米粒子在近红外多光子光动力疗法中有应用的潜力。在存在纳米粒子的近紫外光照射下进行 DNA 的凝胶电泳后，表明嘌呤碱基和 DNA 骨架都受到了损伤。
