Myageri Aneel, Vandana U G, Melkundi Sateesh, Patil Preetam B, Kulkarni Padmaja
Department of Pathology, SDM College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, India.
Department of Neurosurgery, SDM College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, India.
Asian J Neurosurg. 2013 Oct;8(4):195-8. doi: 10.4103/1793-5482.125673.
The diagnosis of primary central nervous system lymphoma (PCNSL) can be suggested by magnetic resonance imaging (MRI). Cerebral PCNSL in immunocompetent patients generally shows marked homogeneous contrast enhancement in MRI. However, confirmation of it requires demonstration of lymphoma cells in stereotactic biopsy of the lesion or in cerebrospinal fluid. In the present case, with radiologic diagnosis of glioma, complete resection of the lesion by micro-neurosurgical technique was performed. The tumor tissue was examined by squash smear, frozen section and paraffin sections. Cytologic appreciation of tumor cells as lymphoid origin in squash smears negated the other possibilities. The immunocytochemistry on squash smear and immunohistochemistry on paraffin sections confirmed the diagnosis of diffuse large B cell lymphoma of non-germinal center B cell phenotype.
原发性中枢神经系统淋巴瘤（PCNSL）的诊断可通过磁共振成像（MRI）提示。免疫功能正常患者的脑PCNSL在MRI上通常显示明显的均匀强化。然而，确诊需要在病变的立体定向活检或脑脊液中发现淋巴瘤细胞。在本病例中，根据影像学诊断为胶质瘤，采用显微神经外科技术对病变进行了完整切除。对肿瘤组织进行了压片涂片、冰冻切片和石蜡切片检查。压片涂片中肿瘤细胞的细胞学评估显示为淋巴源性，排除了其他可能性。压片涂片的免疫细胞化学和石蜡切片的免疫组织化学证实诊断为非生发中心B细胞表型的弥漫性大B细胞淋巴瘤。
