National Reference Laboratory of Gastroenteric Viruses, ÁNTSZ Regional Institute of State Public Health Service, Pécs, Hungary.
Rev Med Virol. 2011 Jan;21(1):32-41. doi: 10.1002/rmv.677.
Kobuviruses are members of the large and growing family Picornaviridae. Until now, two official, Aichi virus and Bovine kobuvirus, and one candidate kobuvirus species, 'porcine kobuvirus', have been identified in human, cattle and swine, respectively. In addition, kobu-like viruses were detected very recently in the bat. Aichi virus could be one of the causative agents of gastroenteritis in humans, and kobuviruses probably also cause diarrhoea in cattle and swine. Although Aichi virus has been detected relatively infrequently (0-3%) in human diarrhoea, high seroprevalence, up to 80-95% at the age of 30-40, was found indicating the general nature of infection in different human populations. In the previous years, much new information has accumulated relating to kobuviruses and their host species. This review summarises the current knowledge on kobuviruses including taxonomy, biology and viral characteristics, and covers all aspects of infection including epidemiology, clinical picture, host species diversity, laboratory diagnosis and it gives a summary about possible future perspectives.
Kobuviruses 是大型且不断增长的小 RNA 病毒科的成员。迄今为止，已在人类、牛和猪中分别鉴定出两种官方的 Aichi 病毒和牛科病毒以及一种候选的科病毒种，即“猪科病毒”。此外，最近在蝙蝠中也检测到了类似科的病毒。Aichi 病毒可能是人类肠胃炎的病原体之一，而科病毒也可能导致牛和猪腹泻。尽管 Aichi 病毒在人类腹泻中检测到的频率相对较低（0-3%），但高达 30-40 岁时 80-95%的高血清阳性率表明了不同人群中感染的普遍性。在过去的几年中，与科病毒及其宿主物种相关的大量新信息不断积累。本综述总结了科病毒的最新知识，包括分类学、生物学和病毒特性，并涵盖了感染的各个方面，包括流行病学、临床图片、宿主物种多样性、实验室诊断，并对可能的未来前景进行了总结。
