Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland.
Pharmacol Biochem Behav. 2011 May;98(3):356-61. doi: 10.1016/j.pbb.2011.01.019. Epub 2011 Feb 2.
The aim of the study is to investigate the effect of adenosine receptor agonists on the development of morphine-induced sensitization to the locomotor activity of mice. Selective A1 (N⁶-cyclopentyladenosine - CPA) and A2A (2-p-(2-carboxyethyl) phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride - CGS 21680) adenosine receptor agonists or non-selective A1/A2A (5'-N-ethylcarboxamidoadenosine - NECA) adenosine agonists as representatives of adenosinergic drugs have been used in the experiment. Behavioral sensitization has been obtained by sporadic treatment with morphine (10.0mg/kg, i.p.). We have shown that adenosine receptor agonists co-administered with morphine significantly attenuates increase in the locomotor activity of mice evoked by challenge dose of morphine. These effects have been observed after stimulation of the selective A1 or A2A and non-selective A1/A2A adenosine receptors, namely both receptors were involved in morphine-induced sensitization. Thus, we have demonstrated that adenosine agonists are able to inhibit behavioral sensitization induced by sporadic applications of morphine.
本研究旨在探讨腺苷受体激动剂对吗啡诱导的小鼠运动活动敏化发展的影响。选择 A1（N⁶-环戊基腺苷-NCPA）和 A2A（2-对-（2-羧乙基）苯乙氨基-5'-N-乙基羧酰胺基腺苷盐酸盐-CGS 21680）腺苷受体激动剂或非选择性 A1/A2A（5'-N-乙基羧酰胺基腺苷-NECA）腺苷激动剂作为代表腺苷能药物在实验中被使用。通过间歇性给予吗啡（10.0mg/kg，ip）获得行为敏化。我们已经表明，与吗啡同时给予的腺苷受体激动剂显著减弱了吗啡挑战剂量引起的小鼠运动活动的增加。这些作用在刺激选择性 A1 或 A2A 和非选择性 A1/A2A 腺苷受体后观察到，即两种受体都参与了吗啡诱导的敏化。因此，我们已经证明，腺苷激动剂能够抑制间歇性给予吗啡引起的行为敏化。
