Department of Physiology, MS-508, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536-0298, USA.
Cell Calcium. 2011 May;49(5):306-13. doi: 10.1016/j.ceca.2011.01.001. Epub 2011 Feb 3.
L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca(2+) flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus. Specifically we highlight recent work demonstrating an auto-feedback regulatory pathway whereby the LTCC transcription factor regulates the LTCC. Also discussed is acute and long-term regulation of function by the LTCC-transcription regulator.
L 型钙通道 (LTCC) 影响几乎所有可兴奋细胞的功能。经典的 LTCC 功能是介导跨肌膜的 Ca(2+) 流动。本综述重点介绍了 LTCC 中一个可移动片段的贡献，该片段调节离子通道功能，同时也是核中转录的调节剂。具体来说，我们强调了最近的工作，证明了 LTCC 转录因子通过自动反馈调节途径调节 LTCC。还讨论了 LTCC-转录调节剂对功能的急性和长期调节。
