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Genetic and molecular basis of inflammasome-mediated disease.

作者信息

Hoffman Hal M, Brydges Susannah D

机构信息

Department of Pediatrics, University of California at San Diego, La Jolla, California 92093, USA.

出版信息

J Biol Chem. 2011 Apr 1;286(13):10889-96. doi: 10.1074/jbc.R110.135491. Epub 2011 Feb 4.

Abstract
摘要

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Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome.
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Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome.
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