Qureshi Ahmad Kaleem, Mukhtar Mat Ropi, Hirasawa Yusuke, Hosoya Takahiro, Nugroho Alfarius Eko, Morita Hiroshi, Shirota Osamu, Mohamad Khalit, Hadi A Hamid A, Litaudon Marc, Awang Khalijah
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
Chem Pharm Bull (Tokyo). 2011;59(2):291-3. doi: 10.1248/cpb.59.291.
Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.
从黄梁木（茜草科）的叶子中分离出两种新的吲哚生物碱，新美登木碱A和B（1, 2）。通过二维核磁共振（2D-NMR）和圆二色光谱（CD）以及化学关联对1和2进行了结构解析。新美登木碱A（1）对诱导型一氧化氮合酶（iNOS）有剂量依赖性抑制作用。
