从夹竹桃科（Rubiaceae）植物蔓长春花（Ochreinauclea maingayii（Hook. f.）Ridsd.）的叶子中分离得到的一个新吲哚生物碱—— Neonaucline。

Neonaucline, a new indole alkaloid from the leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae).

机构信息

Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

出版信息

Molecules. 2011 Dec 28;17(1):267-74. doi: 10.3390/molecules17010267.

DOI:10.3390/molecules17010267

PMID:22205092

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6268236/

Abstract

A new indole alkaloid; neonaucline (1), along with six known compounds-Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A-were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1-3 after injection of each sample at 1 × 10(-5) M.

摘要

从 Ochreinauclea maingayii（茜草科）的叶子中分离得到了一种新的吲哚生物碱——新长春碱（1）以及另外六种已知化合物——卡丹明（2）、长春碱（3）、哈尔曼、苯甲酰胺、肉桂酰胺和布伦纳醇 A。此外，还报道了化合物 2 的（13）C-NMR 数据和化合物 3 的（13）C-NMR 数据。通过光谱方法，特别是 1D 和 2D-NMR、IR、UV 和 LCMS-IT-TOF，对这些生物碱的结构进行了阐明。在以 1×10（-5）M 的浓度注射每种样品后，观察到生物碱 1-3 对离体大鼠主动脉具有优异的血管舒张活性。