Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, UK.
AIDS. 2011 Mar 13;25(5):679-89. doi: 10.1097/QAD.0b013e328342ff93.
To estimate the global and regional distribution of HIV-1 subtypes and recombinants between 2000 and 2007.
Country-specific HIV-1 molecular epidemiology data were combined with estimates of the number of HIV-infected people in each country.
Cross-sectional HIV-1 subtyping data were collected from 65 913 samples in 109 countries between 2000 and 2007. The distribution of HIV-1 subtypes in individual countries was weighted according to the number of HIV-infected people in each country to generate estimates of regional and global HIV-1 subtype distribution for the periods 2000-2003 and 2004-2007.
Analysis of the global distribution of HIV-1 subtypes and recombinants in the two periods indicated a broadly stable distribution of HIV-1 subtypes worldwide with a notable increase in the proportion of circulating recombinant forms (CRFs), a decrease in unique recombinant forms (URFs) and an overall increase in recombinants. In 2004-2007, subtype C accounted for nearly half (48%) of all global infections, followed by subtypes A (12%) and B (11%), CRF02_AG (8%), CRF01_AE (5%), subtype G (5%) and D (2%). Subtypes F, H, J and K together cause fewer than 1% of infections worldwide. Other CRFs and URFs are each responsible for 4% of global infections, bringing the combined total of worldwide CRFs to 16% and all recombinants (CRFs along with URFs) to 20%.
The global and regional distributions of individual subtypes and recombinants are broadly stable, although CRFs may play an increasing role in the HIV pandemic. The global diversity of HIV-1 poses a formidable challenge to HIV vaccine development.
估计 2000 年至 2007 年期间全球和地区艾滋病毒 1 型亚型和重组体的分布情况。
将各国特定的艾滋病毒 1 型分子流行病学数据与各国艾滋病毒感染者人数的估计数相结合。
2000 年至 2007 年期间，在 109 个国家共采集了 65913 份艾滋病毒 1 型样本，收集了艾滋病毒 1 型亚型的横断面分类数据。根据每个国家的艾滋病毒感染者人数，对各国艾滋病毒 1 型亚型的分布情况进行加权，以生成 2000-2003 年和 2004-2007 年期间艾滋病毒 1 型亚型在各地区和全球的分布情况估计数。
对这两个时期全球艾滋病毒 1 型亚型和重组体分布情况的分析表明，全球艾滋病毒 1 型亚型的分布基本保持稳定，循环重组形式（CRFs）的比例显著增加，独特重组形式（URFs）的比例下降，重组体的总数增加。2004-2007 年，C 型亚型占全球所有感染的近一半（48%），其次是 A 型（12%）和 B 型（11%）、02_AG 型（8%）、01_AE 型（5%）、G 型（5%）和 D 型（2%）。F、H、J 和 K 型亚型加在一起，造成全球不到 1%的感染。其他重组形式和独特重组形式分别占全球感染的 4%，将全球范围内的重组体总数提高到 16%，所有重组体（重组形式加上独特重组形式）达到 20%。
各亚型和重组体的全球和地区分布基本保持稳定，尽管重组形式可能在艾滋病毒流行中发挥越来越大的作用。艾滋病毒 1 型的全球多样性给艾滋病毒疫苗的开发带来了巨大挑战。
