Li Xiaoshan, Li Wei, Zhong Ping, Fang Kun, Zhu Kexin, Musa Taha Hussein, Song Yue, Du Guoping, Gao Rong, Guo Yan, Yan Wenjuan, Xuan Yang, Wei Pingmin
1 Teaching and Research Office of Epidemiology and Health Statistics, School of Public Health, Southeast University , Nanjing, China .
2 Department of Infectious Disease Prevention and School Health, Nanjing Municipal Center for Disease Control and Prevention , Nanjing, China .
AIDS Res Hum Retroviruses. 2016 Sep;32(9):851-9. doi: 10.1089/AID.2016.0029. Epub 2016 Jun 16.
To estimate the nationwide and regional distribution of HIV-1 genotypes in China in the past three decades, province-specific HIV-1 molecular epidemiology data were derived from 260 independent studies of HIV molecular prevalence through searching PubMed, VIP Chinese Journal Database (VIP), China National Knowledge Infrastructure, and Wanfang Data from January 1981 to December 2015. The nationwide and regional distribution of HIV-1 genotypes was estimated by weighting the genotype distribution from each province- and risk-specific subpopulation with the number of reported cases in the corresponding subgroups in the relevant periods. A sharp transition of HIV-1 subtypes and recombinant distribution was observed in various risk groups and regions over time. CRF01_AE has rapidly surged among almost all risk groups and in all areas, and it has become dominant among men who have sex with men and heterosexuals. A wide variety of new circulating recombinant forms (CRFs) and unique recombinant forms (URFs) were rapidly appearing in several risk groups and regions. After 2007, CRF01_AE was the most prevalent strain, accounting for 42.5% of all national infections, followed by CRF07_BC (28.9%), subtype B'/B (10.9%), CRF08_BC (10.0%), and subtype C (2.8%). URFs and other CRFs were responsible for 2.6% and fewer than 1% of infections nationwide, respectively. The nationwide and regional distributions of HIV-1 subtypes and recombinants were sharply shifting in China. CRF01_AE and new CRFs played an increasing role in the nationwide or regional HIV pandemic. The nationwide diversity of HIV-1 poses a formidable challenge to HIV vaccine development and disease prevention.
为估算过去三十年中国HIV-1基因型在全国及各地区的分布情况，通过检索1981年1月至2015年12月期间的PubMed、维普中文科技期刊数据库（VIP）、中国知网和万方数据，从260项关于HIV分子流行率的独立研究中获取了特定省份的HIV-1分子流行病学数据。通过用各时期相应亚组中报告病例数对每个省份及风险特定亚人群的基因型分布进行加权，估算了HIV-1基因型在全国及各地区的分布。随着时间推移，在不同风险组和地区观察到HIV-1亚型和重组体分布的急剧转变。CRF01_AE在几乎所有风险组和所有地区迅速激增，并在男男性行为者和异性恋者中成为主导型。多种新的流行重组型（CRF）和独特重组型（URF）在几个风险组和地区迅速出现。2007年后，CRF01_AE是最流行的毒株，占全国所有感染的42.5%，其次是CRF07_BC（28.9%）、B'/B亚型（10.9%）、CRF08_BC（10.0%）和C亚型（2.8%）。URF和其他CRF分别占全国感染的2.6%和不到1%。中国HIV-1亚型和重组体的全国及地区分布正在急剧变化。CRF01_AE和新的CRF在全国或地区的HIV大流行中发挥着越来越大的作用。HIV-1在全国范围内的多样性对HIV疫苗研发和疾病预防构成了巨大挑战。
