Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Am J Clin Oncol. 2012 Oct;35(5):498-503. doi: 10.1097/COC.0b013e318201a3ef.
During the second half of the 20th century, organ transplantation saved thousands of lives. This, unfortunately, also led to unforeseen consequences that need to be addressed to help extend the lives of patients who require these life-saving procedures. Secondary malignancies have been recognized as a potential consequence for decades. One of these malignancies, squamous cell carcinoma of the skin, not only appears more frequently in organ transplant recipients than the general population, but also is more aggressive in organ transplant recipients. It also shows a high propensity to nodal spread and metastasis in transplant patients. Unfortunately, there are no clear guidelines for a chemotherapy in this population, who have an increased need for alternative therapies to surgery given the high recurrence and metastasis rate. In this review, we attempt to describe the characteristics of squamous cell carcinoma of the skin in transplant recipients and discuss what chemotherapeutic options can be used to treat this aggressive malignancy.
在 20 世纪后半叶，器官移植挽救了数千人的生命。但不幸的是，这也带来了意想不到的后果，需要加以解决，以帮助延长需要这些救命手术的患者的生命。继发性恶性肿瘤几十年来一直被认为是一种潜在的后果。其中一种恶性肿瘤，皮肤鳞状细胞癌，不仅在器官移植受者中比普通人群更常见，而且在器官移植受者中更具侵袭性。它在移植患者中也显示出淋巴结转移和转移的高倾向。不幸的是，对于这些人群，由于复发和转移率高，除了手术之外，他们对替代疗法的需求增加，因此针对这类人群，并没有明确的化疗指南。在这篇综述中，我们试图描述皮肤鳞状细胞癌在移植受者中的特征，并讨论可以使用哪些化疗方案来治疗这种侵袭性恶性肿瘤。
