自身免疫性肠道疾病。
Autoimmune bowel disease.
出版信息
Can Fam Physician. 1979 Mar;25:323-6.
The gastrointestinal tract is one of the major lymphatic organs of the body. It is capable of many immunological responses and is exposed to more foreign antigens and pathogens than any other part of the body. Because of the complexity of the GI tract and the difficulty in studying normal responses, even the normal physiology of the immunological aspects of the bowel are not fully understood.Definite abnormalities in immunity are apparent in some GI diseases; the three most common are pernicious anemia, ulcerative colitis, and Crohn's disease. Many of the abnormal immune states seen in these diseases, the possibilities of autoimmunity, some of the extra-intestinal manifestations of these diseases and their possible relationship to an autoimmune state are discussed in this article.
胃肠道是人体主要的淋巴器官之一。它能够进行多种免疫反应，并且比身体的任何其他部位暴露于更多的外来抗原和病原体。由于胃肠道的复杂性和研究正常反应的困难，即使是肠道免疫方面的正常生理学也尚未完全了解。在某些胃肠道疾病中，免疫功能明显异常；最常见的三种是恶性贫血、溃疡性结肠炎和克罗恩病。本文讨论了这些疾病中所见的许多异常免疫状态、自身免疫的可能性、这些疾病的一些肠外表现及其与自身免疫状态的可能关系。
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