Mathur S, Burdash N M, Williamson H O
Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston 29425.
Autoimmunity. 1990;6(3):183-93. doi: 10.3109/08916939009041038.
Sixty six infertile men with cytotoxic sperm antibodies had fewer and lower percentages of OKT4-positive helper/inducer T lymphocytes p = 0.004 and 0.003, respectively), than the fertile (n = 14) and infertile (n = 12) antibody-negative controls. Ratio of OKT4/OKT8 was decreased (p less than 0.01), while numbers of OKDR and BD-Leu12 positive predominantly B lymphocytes were increased (p less than 0.0001) in infertile men with sperm antibodies. T lymphocytes positive for OKT3, OKT11 and OKT4 and the OKT4/OKT8 ratio were decreased in infertile women with sperm antibodies, while B lymphocytes positive for OKDR and BD-Leu12 were increased in infertile women with or without sperm antibodies (p less than 0.0001, versus fertile controls). Lymphocyte responses to phytohemagglutinin (PHA), concanavalin A (ConA) and pokeweed mitogen (PWM), however, were similar in 20 fertile and 136 infertile couples. Lymphocytes from infertile men with sperm antibodies had an enhanced stimulatory response to autologous sperm and seminal plasma. It is concluded that sperm antigens from autoimmune infertile men stimulate heightened immune responses to sperm antigens and altered distribution of white cell populations in both partners.
66名患有细胞毒性精子抗体的不育男性，其OKT4阳性辅助/诱导性T淋巴细胞的数量和百分比分别低于可育对照组（n = 14）和不育抗体阴性对照组（n = 12）（p分别为0.004和0.003）。在患有精子抗体的不育男性中，OKT4/OKT8比值降低（p < 0.01），而主要为B淋巴细胞的OKDR和BD-Leu12阳性细胞数量增加（p < 0.0001）。在患有精子抗体的不育女性中，OKT3、OKT11和OKT4阳性的T淋巴细胞以及OKT4/OKT8比值降低，而无论有无精子抗体的不育女性中，OKDR和BD-Leu12阳性的B淋巴细胞均增加（与可育对照组相比，p < 0.0001）。然而，20对可育夫妇和136对不育夫妇的淋巴细胞对植物血凝素（PHA）、刀豆蛋白A（ConA）和商陆有丝分裂原（PWM）的反应相似。患有精子抗体的不育男性的淋巴细胞对自身精子和精浆的刺激反应增强。结论是，自身免疫性不育男性的精子抗原刺激对精子抗原的免疫反应增强，并改变了双方白细胞群体的分布。
