Lefranc M P
URA CNRS 1191, Université Montpellier II, France.
Eur Cytokine Netw. 1990 Aug-Sep;1(3):121-30.
T lymphocytes recognize antigens through their membrane bound T-cell receptors. Whereas the conventional T-cell receptors are heterodimers of alpha and beta chains, expressed at the surface of CD3+ CD4+ and CD3+ CD8+ T lymphocytes, the gamma delta T-cell receptors are found at the surface of a subset of T-lymphocytes of phenotype CD3+ CD4- CD8-. The synthesis of the T-cell receptor chains results from the junction (or rearrangement) of DNA segments: Variable (V) gene and joining (J) segment for the alpha and gamma chains, V gene, D (diversity) and J segments for the beta and delta chains. In this review, we summarize the recent findings on the genomic organization of the alpha, beta, gamma and delta T-cell receptor loci in human.
T淋巴细胞通过其膜结合的T细胞受体识别抗原。传统的T细胞受体是α和β链的异二聚体，表达于CD3+ CD4+和CD3+ CD8+ T淋巴细胞表面，而γδ T细胞受体则存在于表型为CD3+ CD4- CD8-的T淋巴细胞亚群表面。T细胞受体链的合成是由DNA片段的连接（或重排）产生的：α链和γ链的可变（V）基因和连接（J）片段，β链和δ链的V基因、多样性（D）和J片段。在这篇综述中，我们总结了关于人类α、β、γ和δ T细胞受体基因座基因组组织的最新发现。
