Giudicelli V, Chaume D, Bodmer J, Müller W, Busin C, Marsh S, Bontrop R, Marc L, Malik A, Lefranc M P
Laboratoire d'ImmunoGénétique Moléculaire, LIGM, UMR CNRS 5535, BP5051, 1919 route de Mende, 34033 Montpellier Cedex 1, France.
Nucleic Acids Res. 1997 Jan 1;25(1):206-11. doi: 10.1093/nar/25.1.206.
IMGT, the international ImMunoGeneTics database, is an integrated database specializing in immunoglobulins, T-cell receptors (TcR) and major histocompatibility complex (MHC) of all vertebrate species, initiated and co-ordinated by Marie-Paule Lefranc, CNRS, Montpellier II University, Montpellier, France (lefranc@ligm.crbm.cnrs-mop.fr). IMGT includes two databases: LIGM-DB (for immunoglobulins and TcR) and MHC/HLA-DB. IMGT comprises expertly annotated sequences and alignment tables. LIGM-DB contains more than 19 000 immunoglobulin and TcR sequences from 78 species. MHC/HLA-DB contains class I and class II human leukocyte antigen alignment tables. An IMGT tool, DNAPLOT, developed for immunoglobulins, TcR and MHC sequence alignments, is also available. IMGT works in close collaboration with the EMBL database. IMGT goals are to establish a common data access to all immunogenetics data, including sequences, oligonucleotide primers, gene maps and other genetic data of immunoglobulins, TcR and MHC molecules, and to provide a graphical user-friendly data access. IMGT will have important implications in medical research (repertoire in autoimmune diseases, AIDS, leukemias, lymphomas), therapeutical approaches (antibody engineering), genome diversity and genome evolution studies. IMGT can be accessed at http://imgt.cnusc.fr:8104 and http://www.ebi.ac.uk/IMGT
国际免疫基因数据库（IMGT）是一个专门整合所有脊椎动物物种免疫球蛋白、T细胞受体（TcR）和主要组织相容性复合体（MHC）的数据库，由法国蒙彼利埃第二大学法国国家科学研究中心的玛丽 - 保罗·勒弗朗克发起并协调（lefranc@ligm.crbm.cnrs - mop.fr）。IMGT包括两个数据库：LIGM - DB（用于免疫球蛋白和TcR）和MHC/HLA - DB。IMGT包含经过专业注释的序列和比对表。LIGM - DB包含来自78个物种的19000多条免疫球蛋白和TcR序列。MHC/HLA - DB包含人类白细胞抗原I类和II类的比对表。还有一个为免疫球蛋白、TcR和MHC序列比对开发的IMGT工具DNAPLOT。IMGT与欧洲分子生物学实验室（EMBL）数据库密切合作。IMGT的目标是建立对所有免疫遗传学数据的通用数据访问，包括免疫球蛋白、TcR和MHC分子的序列、寡核苷酸引物、基因图谱和其他遗传数据，并提供图形化的用户友好数据访问。IMGT在医学研究（自身免疫性疾病、艾滋病、白血病、淋巴瘤中的 repertoire）、治疗方法（抗体工程）、基因组多样性和基因组进化研究方面将具有重要意义。可通过http://imgt.cnusc.fr:8104和http://www.ebi.ac.uk/IMGT访问IMGT
