糖尿病与活化部分凝血活酶时间缩短和纤维蛋白原值升高有关。
Diabetes mellitus is associated with shortened activated partial thromboplastin time and increased fibrinogen values.
机构信息
Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
出版信息
PLoS One. 2011 Jan 28;6(1):e16470. doi: 10.1371/journal.pone.0016470.
Abstract
OBJECTIVE
This study was designed to examine the relationship between shortened activated partial thromboplastin time (APTT) and increased fibrinogen values with diabetes mellitus.
METHODS
APTT, prothrombin time (PT), fibrinogen, fasting plasma glucose (FPG) and glycosylated hemoglobin A1c (HbA1c) levels were measured in 1,300 patients. Patients were divided into three groups according to their HbA1c and FPG levels.
RESULTS
When participants were grouped according to their HbA1c levels, we found significantly shorter APTT values (26.9±5.6 s) and increased fibrinogen levels (3.1, 1.9-6.3 g/L) in the diabetes group when compared with the other two groups. When participants were grouped according to their FPG levels, we found significantly shorter APTT values (26.9±6.2 s) and increased fibrinogen levels (3.1, 1.8-6.2 g/L) in the diabetes group when compared with the euglycemic group.
CONCLUSIONS
Shorter APTT and increased fibrinogen levels might be useful hemostatic markers in patients with diabetes and in patients at high risk for diabetes.
摘要
目的
本研究旨在探讨活化部分凝血活酶时间（APTT）缩短和纤维蛋白原值升高与糖尿病之间的关系。
方法
对 1300 例患者的 APTT、凝血酶原时间（PT）、纤维蛋白原、空腹血糖（FPG）和糖化血红蛋白 A1c（HbA1c）水平进行了测量。根据患者的 HbA1c 和 FPG 水平将其分为三组。
结果
当根据 HbA1c 水平对参与者进行分组时，与其他两组相比，糖尿病组的 APTT 值明显缩短（26.9±5.6 s），纤维蛋白原水平升高（3.1，1.9-6.3 g/L）。当根据 FPG 水平对参与者进行分组时，与血糖正常组相比，糖尿病组的 APTT 值明显缩短（26.9±6.2 s），纤维蛋白原水平升高（3.1，1.8-6.2 g/L）。
结论
APTT 缩短和纤维蛋白原水平升高可能是糖尿病患者和糖尿病高危患者有用的止血标志物。
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