A rational approach to the development of antiviral chemotherapy: alternative substrates of herpes simplex virus Type 1 (HSV-1) and Type 2 (HSV-2) thymidine kinase (TK).

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作者信息

Cheng Y C

出版信息

Ann N Y Acad Sci. 1977 Mar 4;284:594-8. doi: 10.1111/j.1749-6632.1977.tb21992.x.

DOI:10.1111/j.1749-6632.1977.tb21992.x

PMID:212988

Abstract

摘要

相似文献

A rational approach to the development of antiviral chemotherapy: alternative substrates of herpes simplex virus Type 1 (HSV-1) and Type 2 (HSV-2) thymidine kinase (TK).

Ann N Y Acad Sci. 1977 Mar 4;284:594-8. doi: 10.1111/j.1749-6632.1977.tb21992.x.

The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase.A167Y突变将单纯疱疹病毒1型胸苷激酶转变为鸟嘌呤类似物激酶。

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Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.通过将丙氨酸-167突变为酪氨酸选择性消除单纯疱疹病毒1型胸苷激酶的嘧啶核苷激酶活性。

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Mechanism and mode of action of 5-iodo-2-pyrimidinone 2'-deoxyribonucleoside, a potent anti-herpes simplex virus compound, in herpes simplex virus-infected cells.

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Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.胸苷酸合成酶是（E）-5-（2-溴乙烯基）-2'-脱氧尿苷对用1型或2型单纯疱疹病毒胸苷激酶基因转化的小鼠乳腺癌（FM3A）细胞的细胞生长抑制活性的主要靶酶。

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Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells.嘧啶核苷对哺乳动物细胞中单纯疱疹病毒1型胸苷激酶（HSV-1 TK）表达成像的细胞毒性和细胞摄取

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Synthesis, 18F-radiolabelling and biological evaluations of C-6 alkylated pyrimidine nucleoside analogues.C-6烷基化嘧啶核苷类似物的合成、18F放射性标记及生物学评价

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Potent activity of 5-fluoro-2'-deoxyuridine and related compounds against thymidine kinase-deficient (TK-) herpes simplex virus: targeted at thymidylate synthase.5-氟-2'-脱氧尿苷及相关化合物对胸苷激酶缺陷型（TK-）单纯疱疹病毒具有强效活性：作用于胸苷酸合成酶。

Mol Pharmacol. 1987 Aug;32(1):286-92.

Phosphonoamidate prodrugs of C5-substituted pyrimidine acyclic nucleosides for antiviral therapy.用于抗病毒治疗的C5-取代嘧啶无环核苷的膦酰氨基酯前药。

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Effect of treatment with 1-beta-D-arabinofuranosylthymine of experimental encephalitis induced by herpes simplex virus in mice.1-β-D-阿拉伯呋喃糖基胸腺嘧啶对单纯疱疹病毒诱导的小鼠实验性脑炎的治疗效果。

Antimicrob Agents Chemother. 1980 Feb;17(2):109-14. doi: 10.1128/AAC.17.2.109.

Biochemical characterization of equine herpesvirus type 3-induced deoxythymidine kinase purified from lytically infected horse embryo dermal fibroblasts.从经裂解感染的马胚胎皮肤成纤维细胞中纯化的马疱疹病毒3型诱导的脱氧胸苷激酶的生化特性

J Virol. 1980 May;34(2):474-83. doi: 10.1128/JVI.34.2.474-483.1980.

Efficacy and selectivity of some nucleoside analogs as anti-human cytomegalovirus agents.某些核苷类似物作为抗人巨细胞病毒药物的疗效和选择性。

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Susceptibility of recent clinical isolates of herpes simplex virus to 5-ethyl-2'-deoxyuridine: preferential inhibition of herpes simplex virus type 2.单纯疱疹病毒近期临床分离株对5-乙基-2'-脱氧尿苷的敏感性：对2型单纯疱疹病毒的优先抑制作用

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Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.9-[(1,3-二羟基-2-丙氧基)甲基]鸟嘌呤对疱疹病毒的独特体外活性谱及其对1型单纯疱疹病毒的作用方式

Proc Natl Acad Sci U S A. 1983 May;80(9):2767-70. doi: 10.1073/pnas.80.9.2767.

Capacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity.脱氧胞苷在不丧失抗疱疹活性的情况下，选择性拮抗脱氧胞苷5-卤代类似物细胞毒性的能力。

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In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.水痘带状疱疹病毒对E-5-（2-溴乙烯基）-2'-脱氧尿苷及相关化合物的体外敏感性

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