口服积雪草提取物对糖尿病伤口患者促进伤口愈合的疗效及副作用。

The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients.

作者信息

Paocharoen Veeraya

机构信息

Department of Surgery, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.

出版信息

J Med Assoc Thai. 2010 Dec;93 Suppl 7:S166-70.

PMID:21298840

Abstract

OBJECTIVE

To study clinical efficacy and side effects of the oral Centella asiatica extract capsule in the diabetic wound healing. And to study the side effects of Centella asiatica extract capsule.

MATERIAL AND METHOD

This prospective randomized control study enrolled two hundred diabetic patients in the department of Surgery, Thammasat University Hospital. The exclusion criterion were low immune patients, oral steroid intake, age more than 80 year and less than 18 yeas, serum albumin less than 3.0 gm/dl, uncorrected peripheral arterial diseased patients, and uncontrolled infective wound. The termination criterion were patient refusal, wound infection, delayed primary sutured wound secondary healing wound. The patients were divided into two groups randomly, groupA was Centella asiatica extract capsule group and group B was placebo group. Centella asiatica extract capsule and placebo were prescribed in each group under the random sheet. The administration was 2 capsules after meal, three times a day (50 mg of extracted asiaticoside / capsule in group A). The general symptoms, wound characteristics, wound size and depth were examined at day 7, day 14 and day 21 by the same investigator. The demographic data of the sample were analyzed by student t test and comparative wound characteristics were analyzed by Pearson Chi-Square test.

RESULTS

Wound contraction in the study group is better than placebo group but granulation tissue forming is better in the placebo group. No serious adverse reaction in both groups.

CONCLUSION

Centella asiatica extract capsule is the Thai herb preparation capsule that effective in the wound healing promotion and also suppress the scar in diabetic wound patients. There was no demonstrable serious side effect of the Centella asiatica extract capsule group. Centella asiatica extract capsule can shorten the course of diabetic wound and can be prescribed to the diabetic patients safely.

摘要

目的

研究口服积雪草提取物胶囊对糖尿病伤口愈合的临床疗效及副作用。并研究积雪草提取物胶囊的副作用。

材料与方法

这项前瞻性随机对照研究纳入了泰国国立法政大学医院外科的200名糖尿病患者。排除标准为免疫功能低下患者、口服类固醇药物、年龄超过80岁或低于18岁、血清白蛋白低于3.0 gm/dl、未矫正的外周动脉疾病患者以及未控制的感染性伤口。终止标准为患者拒绝、伤口感染、延迟一期缝合伤口、二期愈合伤口。患者被随机分为两组，A组为积雪草提取物胶囊组，B组为安慰剂组。根据随机表在每组中开具积雪草提取物胶囊和安慰剂。给药方式为饭后服用2粒胶囊，每日3次（A组每粒胶囊含50mg积雪草苷提取物）。由同一名研究者在第7天、第14天和第21天检查一般症状、伤口特征、伤口大小和深度。样本的人口统计学数据采用学生t检验进行分析，比较伤口特征采用Pearson卡方检验进行分析。