来自海洋海绵Aaptos sp.的三种新型aaptamine及其促凋亡特性。
Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties.
作者信息
Shubina Larisa K, Makarieva Tatyana N, Dyshlovoy Sergey A, Fedorov Sergey N, Dmitrenok Pavel S, Stonik Valentin A
机构信息
Laboratory of Chemistry MaNaPro, Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 690022 Vladivostok, Russia.
出版信息
Nat Prod Commun. 2010 Dec;5(12):1881-4.
Three new aaptamine-type alkaloids, 2,3-dihydro-2,3-dioxoaaptamine (1), 6-(N-morpholinyl)-4,5-dihydro-5-oxo-demethyl(oxy)aaptamine (2) and 3-(methylamino)demethyl(oxy)aaptamine (3), along with known aaptamines were isolated from the sponge Aaptos sp. Their structures were determined on the basis of detailed analysis of their 1D and 2D NMR spectroscopic and mass spectral data. The isolated compounds induced apoptosis in human leukemia THP-1 cells.
从海绵Aaptos sp.中分离出三种新的aaptamine型生物碱，即2,3-二氢-2,3-二氧代aaptamine（1）、6-（N-吗啉基）-4,5-二氢-5-氧代去甲基（氧基）aaptamine（2）和3-（甲氨基）去甲基（氧基）aaptamine（3），以及已知的aaptamines。它们的结构是基于对其一维、二维核磁共振光谱和质谱数据的详细分析确定的。分离出的化合物可诱导人白血病THP-1细胞凋亡。
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