通过无铜点击反应首次实现了硼烷修饰 DNA 的化学合成。
The first chemical synthesis of boronic acid-modified DNA through a copper-free click reaction.
机构信息
Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30302-4098, USA.
出版信息
Chem Commun (Camb). 2011 Mar 28;47(12):3598-600. doi: 10.1039/c0cc04546b. Epub 2011 Feb 8.
PMID:21301752
Abstract
The first chemical incorporation of the boronic acid group into DNA using a copper-free click reagent was reported. Compared with the PCR-based method, this approach allows for site-specific incorporation and synthesis on a larger scale.
摘要
首次使用无铜点击试剂将硼酸基团化学掺入 DNA 中。与基于 PCR 的方法相比，该方法允许在更大的规模上进行特定部位的掺入和合成。
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