Martínez S M, Tarrés M C, Montenegro S, Revelant G, Figueroa N, Alonso D, Laudanno O M, D'Ottavio A
Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
Acta Diabetol Lat. 1990 Oct-Dec;27(4):329-36. doi: 10.1007/BF02580937.
eSS rats exhibit a non-insulin-dependent diabetic syndrome, significantly influenced by diet. Long-term effects of intermittent dietary restriction were studied in male eSS rats. Experimental animals were fed ad libitum during 48 h and food-deprived the next 24 h (R) while controls (L) of the same strain were freely fed every day. This schedule was maintained from 21 days of age until all rats were sacrificed. R animals were leaner than L rats at 5, 8 and 13 months of age. Moreover, an improved metabolic profile (i.e., lower levels in blood triglycerides, total blood cholesterol, basal blood glucose and blood glucose after an oral glucose load) was found. Histological examination of nuchal skin specimens showed a significant increase of dermal thickness and epidermal hypotrophy in free-fed animals. Collagenous fibers closely packed were found just beneath the dermo-epidermal junction in L rats. This finding was less pronounced in R rats. The above mentioned results suggest that eSS rats would draw advantage from living in environments where food availability is uncertain. The importance of early dietary restrictions in predisposed genotypes appears to be a valuable preventive measure against diabetic evolution and complications.
eSS大鼠表现出非胰岛素依赖型糖尿病综合征，受饮食影响显著。对雄性eSS大鼠间歇性饮食限制的长期影响进行了研究。实验动物在48小时内随意进食，接下来的24小时禁食（R组），而同一品系的对照组（L组）每天自由进食。从21日龄开始维持此时间表，直到所有大鼠被处死。在5、8和13月龄时，R组动物比L组动物更瘦。此外，还发现代谢状况有所改善（即血液甘油三酯、总胆固醇、基础血糖和口服葡萄糖负荷后血糖水平降低）。对颈部皮肤标本的组织学检查显示，自由进食动物的真皮厚度显著增加，表皮萎缩。在L组大鼠的真皮-表皮交界处下方发现紧密排列的胶原纤维。这一发现在R组大鼠中不太明显。上述结果表明，eSS大鼠若生活在食物供应不确定的环境中可能会受益。对易感基因型进行早期饮食限制的重要性似乎是预防糖尿病进展和并发症的一项有价值的预防措施。
