Zang X X, Qian B C, Liu J
Department of Pharmacology, Zhejiang Academy of Medicine, Hangzhou, China.
Zhongguo Yao Li Xue Bao. 1990 Sep;11(5):477-80.
The bone marrow as a source of serum hemolysin to sheep red blood cells (SRBC) was studied in splenectomized mice. Splenectomy prevented the hemolysin formation in the primary response, but not in the secondary response. Cyclophosphamide 100 mg/kg and dexamethasone 10 mg/kg decreased hemolysin formation in the bone marrow as well as in the spleen. Levamisole 50 mg/kg increased its formation in both organs. Prednisolone 10 mg/kg significantly suppressed its formation in the spleen, but not in the bone marrow. Hydroxyurea 50 mg/kg suppressed its formation in the bone marrow, but not in the spleen. These results suggest that the bone marrow is the major source of serum hemolysin to SRBC during the secondary response and drug has different effects on antibody production in the bone marrow and in the spleen.
在脾切除小鼠中研究了骨髓作为血清抗绵羊红细胞（SRBC）溶血素来源的情况。脾切除可阻止初次反应中溶血素的形成，但对二次反应无此作用。100mg/kg环磷酰胺和10mg/kg地塞米松可降低骨髓和脾脏中溶血素的形成。50mg/kg左旋咪唑可增加两个器官中溶血素的形成。10mg/kg泼尼松龙可显著抑制脾脏中溶血素的形成，但对骨髓无此作用。50mg/kg羟基脲可抑制骨髓中溶血素的形成，但对脾脏无此作用。这些结果表明，在二次反应期间，骨髓是血清抗SRBC溶血素的主要来源，且药物对骨髓和脾脏中抗体产生的作用不同。
