The Genome Center at Washington University School of Medicine, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.
Nature. 2011 Feb 10;470(7333):198-203. doi: 10.1038/nature09796.
The decade since the Human Genome Project ended has witnessed a remarkable sequencing technology explosion that has permitted a multitude of questions about the genome to be asked and answered, at unprecedented speed and resolution. Here I present examples of how the resulting information has both enhanced our knowledge and expanded the impact of the genome on biomedical research. New sequencing technologies have also introduced exciting new areas of biological endeavour. The continuing upward trajectory of sequencing technology development is enabling clinical applications that are aimed at improving medical diagnosis and treatment.
人类基因组计划结束后的十年见证了测序技术的惊人爆炸式发展，使得人们能够以前所未有的速度和分辨率提出并回答大量有关基因组的问题。在这里，我将举例说明这些信息如何增强了我们的知识，并扩大了基因组对生物医学研究的影响。新的测序技术也为生物研究领域带来了令人兴奋的新方向。测序技术的持续发展为改善医疗诊断和治疗的临床应用提供了可能。
