Can Fam Physician. 1976 Mar;22:62-6.
Fourteen patients with asthma have been followed in a long term clinical trial of the inhaled synthetic corticosteroid, beclomethasone dipropionate. All the patients were corticosteroid-dependent, with significant corticosteroid adverse effects. Twelve of the patients were able to stay on long term beclomethasone dipropionate therapy. Eight were able to discontinue use of systemic corticosteroids. There was a statistically significant reduction in the use of systemic corticosteroids (P<0.01) for the group when they were transferred to beclomethasone dipropionate. There was also an improvement of corticosteroid adverse effects in ten patients, but no significant change in their symptom scores. Several points of caution are stressed concerning long term clinical use of this promising drug.
14 例哮喘患者参与了吸入式合成皮质甾类药物——二丙酸倍氯米松的长期临床试验。所有患者均依赖皮质甾类药物,且伴有明显的皮质甾类药物副作用。12 例患者能够长期接受二丙酸倍氯米松治疗,8 例患者能够停止使用全身皮质甾类药物。当他们转为使用二丙酸倍氯米松时,全身皮质甾类药物(P<0.01)的使用明显减少。10 例患者的皮质甾类药物副作用也有所改善,但他们的症状评分没有明显变化。在长期临床使用这种有前景的药物时,需要强调几点注意事项。