Xu Lili, Li Xiaohong, Dai Li, Yuan Xiuqin, Liang Juan, Zhou Guangxuan, Li Qi, He Chunhua, Miao Lei, Wang Yanping, Zhu Jun
National Center for Birth Defect Monitoring, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
Birth Defects Res A Clin Mol Teratol. 2011 Mar;91(3):177-84. doi: 10.1002/bdra.20753. Epub 2011 Feb 9.
In recent years, the prevalence of gastroschisis has increased remarkably in some areas and remained unchanged in other areas; however, in general, there is a recent increasing trend compared to the 1970s and 1980s. In this study, we explored the time trend of gastroschisis prevalence in China during 1996 to 2007.
Data were retrieved from the hospital-based national monitoring database maintained by the Chinese Birth Defects Monitoring Network (CBDMN). The monitored subjects were infants born on the 28th gestational week or later, including live births and stillbirths. The maximal time for the diagnosis of a congenital malformation was the seventh day after birth. The secular trends on the overall prevalence and the different feature-specific prevalence of gastroschisis in China were analyzed using the linear chi-square test and the Poisson regression model.
The overall prevalence of gastroschisis in China was 2.54 per 10,000 births during 1996 to 2007. Except for the prevalence of gastroschisis that significantly increased among infants whose mothers were 20 to 24 years old (p=0.0498 for the linear chi-square test, p=0.0032 for the Poisson regression model analysis) and significantly decreased among infants whose mothers were 30 to 34 years old (p=0.0177 for the Poisson regression model analysis), no significant changes were found in the overall and remaining feature-specific prevalences.
The overall prevalence of gastroschisis in China did not change remarkably during 1996 to 2007; but the prevalence of gastroschisis significantly increased among infants whose mothers were 20 to 24 years old and decreased among infants whose mothers were 30 to 34 years old.
近年来，腹裂的患病率在一些地区显著上升，在其他地区则保持不变；然而，总体而言，与20世纪70年代和80年代相比，近期呈上升趋势。在本研究中，我们探讨了1996年至2007年中国腹裂患病率的时间趋势。
数据取自中国出生缺陷监测网络（CBDMN）维护的基于医院的全国监测数据库。监测对象为孕28周及以后出生的婴儿，包括活产儿和死产儿。先天性畸形的最大诊断时间为出生后第七天。采用线性卡方检验和泊松回归模型分析中国腹裂总体患病率及不同特征特异性患病率的长期趋势。
1996年至2007年中国腹裂的总体患病率为每10000例出生2.54例。除母亲年龄在20至24岁的婴儿腹裂患病率显著上升（线性卡方检验p = 0.0498，泊松回归模型分析p = 0.0032）以及母亲年龄在30至34岁的婴儿腹裂患病率显著下降（泊松回归模型分析p = 0.0177）外，总体患病率及其他特征特异性患病率均无显著变化。
1996年至2007年中国腹裂的总体患病率无显著变化；但母亲年龄在20至24岁的婴儿腹裂患病率显著上升，母亲年龄在30至34岁的婴儿腹裂患病率下降。
