Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Institute for Prevention and Control of Infection and Infectious Diseases, Liaoning Provincial Center for Disease Control and Prevention, Shenyang, China.
Int J Public Health. 2022 Jul 7;67:1604945. doi: 10.3389/ijph.2022.1604945. eCollection 2022.
To examine associations between maternal sulfur dioxide (SO) exposure and congenital ear malformations risk in offspring. We surveyed 1676 cases with congenital ear malformations and 7950 controls from the Maternal and Child Health Certificate Registry of Liaoning Province between 2010 and 2015. SO concentrations were obtained from the Municipal Environment Protection Bureau of Liaoning Province. Multivariable logistic regression models and Restricted cubic splines (RCS) model were used to assess the aforementioned association. There were significant associations between maternal SO exposure and congenital ear malformations risk during the 3 months before conception (OR = 1.93, 95% CI = 1.43-2.59) and the 3 months after conception (OR = 1.63, 95% CI = 1.22-2.18). Similar results were obtained in the analysis of single-month exposure windows, except for the third month before conception and the third month after conception. Moreover, these findings were broadly consistent across subgroups and robust in sensitivity analyses. There were non-linear dose-response associations between SO exposure and congenital ear malformations based on restricted cubic spline model analysis. Maternal SO exposure is associated with increased congenital ear malformations risk in offspring.
探讨母体二氧化硫（SO）暴露与子代先天性耳畸形风险之间的关联。
我们调查了 2010 年至 2015 年辽宁省母婴健康证注册处的 1676 例先天性耳畸形病例和 7950 例对照。SO 浓度取自辽宁省市环境保护局。采用多变量逻辑回归模型和受限立方样条（RCS）模型评估上述关联。
在受孕前 3 个月（OR=1.93，95%CI=1.43-2.59）和受孕后 3 个月（OR=1.63，95%CI=1.22-2.18），母体 SO 暴露与先天性耳畸形风险之间存在显著关联。在单月暴露窗口期分析中也得到了类似的结果，但在受孕前 3 个月和受孕后 3 个月除外。此外，这些发现广泛存在于亚组分析中，且在敏感性分析中具有稳健性。基于受限立方样条模型分析，SO 暴露与先天性耳畸形之间存在非线性剂量反应关系。
母体 SO 暴露与子代先天性耳畸形风险增加有关。
