Institut für Organische Chemie, Universität Regensburg, Regensburg, Germany.
Org Lett. 2011 Mar 4;13(5):1102-5. doi: 10.1021/ol103134c. Epub 2011 Feb 10.
A structurally well-defined copper(I) isonitrile complex is shown to be an efficient, heterogeneous catalyst for the Huisgen azide-alkyne 1,3-dipolar cycloaddition under mild conditions in water. Notably, this catalyst can also be utilized in a three-component reaction of halides, sodium azide and alkynes to form 1,4-disubstituted 1,2,3-triazoles in high yields. Furthermore, it can be readily recovered by precipitation and filtration and recycled for at least five runs without significant loss of activity.
一个结构明确的铜（I）异腈配合物被证明是一种高效、非均相催化剂，可在温和条件下、水中实现 Huisgen 叠氮-炔 1,3-偶极环加成反应。值得注意的是，该催化剂还可用于卤代物、叠氮化钠和炔烃的三组分反应，以高产率形成 1,4-二取代的 1,2,3-三唑。此外，它可以通过沉淀和过滤方便地回收，并至少循环使用五次而没有明显的活性损失。
