Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
Wiley Interdiscip Rev RNA. 2011 Jan-Feb;2(1):1-21. doi: 10.1002/wrna.57.
The small subunit (SSU) processome is a 2.2-MDa ribonucleoprotein complex involved in the processing, assembly, and maturation of the SSU of eukaryotic ribosomes. The identities of many of the factors involved in SSU biogenesis have been elucidated over the past 40 years. However, as our understanding increases, so do the number of questions about the nature of this complicated process. Cataloging the components is the first step toward understanding the molecular workings of a system. This review will focus on how identifying components of ribosome biogenesis has led to the knowledge of how these factors, protein and RNA alike, associate with one another into subcomplexes, with a concentration on the small ribosomal subunit. We will also explore how this knowledge of subcomplex assembly has informed our understanding of the workings of the ribosome synthesis system as a whole.
小亚基（SSU）加工体是一个 2.2MDa 的核糖核蛋白复合物，参与真核核糖体的 SSU 的加工、组装和成熟。在过去的 40 年中，已经阐明了许多参与 SSU 生物发生的因素的身份。然而，随着我们的理解的增加，这个复杂过程的性质的问题也越来越多。对成分进行编目是理解系统分子工作原理的第一步。这篇综述将集中讨论如何识别核糖体生物发生的成分，从而了解这些因素，无论是蛋白质还是 RNA，如何彼此相互关联形成亚复合物，特别是小核糖体亚基。我们还将探讨这种亚复合物组装的知识如何使我们对核糖体合成系统整体的工作原理有了更深入的了解。
