The University of Southern Mississippi, Department of Psychology, 118 College Drive, Box 5025, Hattiesburg, MS 39406, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 1;35(6):1416-20. doi: 10.1016/j.pnpbp.2011.01.020. Epub 2011 Feb 12.
Traditionally, rodent sustained attention models are used for studying the neurobiological underpinnings of attention, for assessing the disruptive and interactive effects of drugs and environmental toxins and for predicting the efficacy of pharmacotherapies for attention disorders. Virtually all-major psychiatric disorders are characterized by disturbances in attention or concentration. Additionally, many psychoactive drugs produce simultaneous effects on a variety of psychological processes. Behavioral measures in tasks designed to assess cognitive processes in rodents characterize and dissociate these multiple influences. While the zebrafish (Danio rerio) has been at the vanguard of neurobiological research and is increasing in popularity as a model organism for behavioral applications, their attentional capacity has not been fully assessed. Here we review some of the more popular animal models and discuss the utility of a choice discrimination zebrafish model.
传统上，啮齿动物持续注意力模型用于研究注意力的神经生物学基础，用于评估药物和环境毒素的破坏和交互作用，并预测注意力障碍的药物治疗效果。几乎所有主要的精神疾病都以注意力或集中力障碍为特征。此外，许多精神活性药物会对各种心理过程产生同时作用。在设计用于评估啮齿动物认知过程的任务中，行为测量可以描述和区分这些多种影响。虽然斑马鱼（Danio rerio）一直处于神经生物学研究的前沿，并且作为行为应用的模式生物越来越受欢迎，但它们的注意力能力尚未得到充分评估。在这里，我们回顾了一些更受欢迎的动物模型，并讨论了选择辨别斑马鱼模型的效用。
