Bailey Jordan M, Oliveri Anthony N, Levin Edward D
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Pharmacol Biochem Behav. 2015 Dec;139 Pt B(0 0):103-11. doi: 10.1016/j.pbb.2015.03.006. Epub 2015 Mar 17.
Over the last decade, zebrafish (Danio rerio) have become valuable as a complementary model in behavioral pharmacology, opening a new avenue for understanding the relationships between drug action and behavior. This species offers a useful intermediate approach bridging the gap between in vitro studies and traditional mammalian models. Zebrafish offer great advantages of economy compared to their rodent counterparts, their complex brains and behavioral repertoire offer great translational potential relative to in vitro models. The development and validation of a variety of tests to measure behavior, including cognition, in zebrafish have set the stage for the use of this animal for behavioral pharmacology studies. This has led to research into the basic mechanisms of cognitive function as well as screening for potential cognition-improving drug therapies, among other lines of research. As with all models, zebrafish have limitations, which span pharmacokinetic challenges to difficulties quantifying behavior. The use, efficacy and limitations associated with a zebrafish model of cognitive function are discussed in this review, within the context of behavioral pharmacology.
在过去十年中，斑马鱼（Danio rerio）已成为行为药理学中一种有价值的补充模型，为理解药物作用与行为之间的关系开辟了一条新途径。该物种提供了一种有用的中间方法，弥合了体外研究与传统哺乳动物模型之间的差距。与啮齿动物相比，斑马鱼具有经济上的巨大优势，其复杂的大脑和行为库相对于体外模型具有很大的转化潜力。各种用于测量行为（包括认知）的测试在斑马鱼中的开发和验证，为将这种动物用于行为药理学研究奠定了基础。这引发了对认知功能基本机制的研究以及对潜在认知改善药物疗法的筛选等一系列研究。与所有模型一样，斑马鱼也有局限性，包括药代动力学挑战以及行为量化困难等。本综述在行为药理学的背景下讨论了与斑马鱼认知功能模型相关的用途、功效和局限性。
