School of Dental Medicine, Division of Periodontology and Oral Pathophysiology, University of Geneva, Geneva, Switzerland.
J Clin Periodontol. 2011 Mar;38 Suppl 11:203-13. doi: 10.1111/j.1600-051X.2010.01666.x.
To describe the microbiota associated with peri-implant disease, with a specific emphasis on the differential diagnosis of the condition.
The potentially relevant literature was preliminarily assessed via scoping searches to find the most appropriate search terms and the most efficient Boolean search algorithm. We identified 29 reports on subjects with osseointegrated implants, with a pathological condition compatible with the definition of "peri-implant disease", and reporting microbiological data from samples taken in affected sites.
In most studies bacterial samples were obtained by methods that destroy the three-dimensional structure of the biofilm. The samples therefore describe mixtures of bacteria from unspecified districts of biofilm associated with peri-implant diseases. Analyses of such samples with various methods indicate that peri-implant disease maybe viewed as a mixed anaerobic infection. In most cases the composition of the flora is similar to the subgingival flora of chronic periodontitis that is dominated by Gram-negative bacteria. Peri-implant infections may occasionally be linked to a different microbiota, including high numbers of peptostreptococci or staphylococci. Beneficial effects of mechanical and chemical interventions to disrupt the peri-implant biofilm demonstrate that microorganisms are involved in the disease process, even if they may not always be the origin of the condition.
描述与种植体周围疾病相关的微生物群，并特别强调该疾病的鉴别诊断。
通过范围检索初步评估潜在相关文献，以找到最合适的检索词和最有效的布尔搜索算法。我们确定了 29 篇关于骨整合种植体受试者的报告，这些报告的病理状况与“种植体周围疾病”的定义相符，并报告了来自病变部位样本的微生物学数据。
在大多数研究中，细菌样本是通过破坏生物膜三维结构的方法获得的。因此，这些样本描述了与种植体周围疾病相关的生物膜中来自未指定部位的细菌混合物。使用各种方法对这些样本进行分析表明，种植体周围疾病可能被视为一种混合性厌氧感染。在大多数情况下，菌群的组成与慢性牙周炎的龈下菌群相似，主要为革兰氏阴性菌。种植体周围感染偶尔可能与不同的微生物群有关，包括数量较多的消化链球菌或葡萄球菌。机械和化学干预破坏种植体周围生物膜的有益效果表明，微生物参与了疾病过程，即使它们并不总是疾病的根源。
