Alves Pereira Marta Maria, Piazza Rodolfo, Santana Amanda Paino, Ricardo Barão Valentim Adelino, Malheiros Samuel Santana, van den Beucken Jeroen J J P, de Molon Rafael Scaf, de Avila Erica Dorigatti
Department of Dental Materials and Prosthodontics, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo 14801-903, Brazil.
Department of Physical Chemistry, São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo 14801-970, Brazil.
ACS Biomater Sci Eng. 2025 Jan 13;11(1):13-32. doi: 10.1021/acsbiomaterials.4c01037. Epub 2024 Nov 30.
Peri-implantitis is an inflammatory condition caused by bacterial biofilms adhered on dental implant surfaces that cause progressive tissue destruction from the host's inflammatory response. The adverse effects of peri-implantitis progression can go beyond just losing the implant. This highlights the importance of implementing strategies to stabilize disease in the short term. Layer-by-layer (LbL) assembly is a promising avenue in the field of peri-implantitis management due to its applicability with a variety of substances, in addition to being an easy, versatile, and flexible process for multilayer formation to act directly in the affected site. In this Review, our objective is to offer comprehensive chemical and biological insights into the LbL system, clarifying its specific application as antimicrobial coatings, with concern for the physical site and purpose. Additionally, we delve deeper into the concepts of onset and progression of peri-implantitis, aiming to elucidate the precise indications for employing the LbL system as a coating for implant abutments in peri-implantitis treatment. Finally, we correlate the chemical composition of the LbL system with its functionality while also addressing the challenges posed by the uncontrolled environment of the oral cavity, which ultimately restricts its clinical applicability.
种植体周围炎是一种由附着在牙种植体表面的细菌生物膜引起的炎症性疾病，该生物膜会因宿主的炎症反应导致组织进行性破坏。种植体周围炎进展的不良影响可能不止于失去种植体。这凸显了实施短期稳定病情策略的重要性。层层组装（LbL）由于其可与多种物质结合应用，并且是一种用于形成多层结构以直接作用于感染部位的简单、通用且灵活的过程，因此在种植体周围炎管理领域是一条有前景的途径。在本综述中，我们的目标是提供关于LbL系统全面的化学和生物学见解，阐明其作为抗菌涂层的具体应用，同时关注物理部位和目的。此外，我们更深入地探讨种植体周围炎的发病和进展概念，旨在阐明在种植体周围炎治疗中使用LbL系统作为种植体基台涂层的精确指征。最后，我们将LbL系统的化学成分与其功能相关联，同时也解决口腔不受控制的环境所带来的挑战，这最终限制了其临床应用。
