血浆中半胱氨酰多巴水平升高提示黑素细胞在银屑病中作为应激感受器。

Increased cysteinyldopa plasma levels hint to melanocyte as stress sensor in psoriasis.

出版信息

Exp Dermatol. 2011 Mar;20(3):288-90. doi: 10.1111/j.1600-0625.2010.01211.x.

DOI:10.1111/j.1600-0625.2010.01211.x

Abstract

The possible role of melanocyte as a modulator of the inflammation and keratinocyte hyperproliferation in psoriasis has been hypothesised but never demonstrated on experimental basis. Aim of the present study was to assess whether plasma levels of 5-S-cysteinyldopa (CD), a metabolite reflecting melanocyte activity, undergo changes in association with psoriasis together with those of typical lipid peroxidation markers thiobarbituric acid reactive substances (TBARS). A group of 16 patients with psoriasis at different stage as indicated by the psoriasis area and severity index (PASI) were enrolled against an age and sex matched control group. Both TBARS (P<0.05) and CD (P<0.005) levels were higher than controls with statistical significance. After 1 month therapy the levels of either biomarkers decreased with respect to the starting values although with marked individual differences. CD may represent a novel and sensitive biomarker for the follow up of psoriasis and evaluation of the efficacy of therapeutic regimens beyond PASI determination.

摘要

黑色素细胞在银屑病的炎症和角质形成细胞过度增殖中可能发挥调节作用，但尚未在实验基础上得到证实。本研究的目的是评估血浆中 5-S-半胱氨酸多巴（CD）的水平是否会发生变化，这种代谢物反映了黑色素细胞的活性，与银屑病一起发生变化，同时评估典型的脂质过氧化标志物硫代巴比妥酸反应物质（TBARS）的水平。根据银屑病面积和严重程度指数（PASI），招募了一组 16 名处于不同阶段的银屑病患者作为年龄和性别匹配的对照组。TBARS（P<0.05）和 CD（P<0.005）的水平均显著高于对照组。治疗 1 个月后，两种生物标志物的水平均较起始值下降，但个体差异较大。CD 可能是银屑病随访和评估治疗方案疗效的一种新的、敏感的生物标志物，超越 PASI 测定。