Tzeng Shih-Yu, Guo Jean-Yan, Yang Chao-Chun, Hsu Chao-Kai, Huang Hung Ji, Chou Shih-Jie, Hwang Chi-Hung, Tseng Sheng-Hao
Department of Photonics, National Cheng Kung University, Tainan, 701, Taiwan.
Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan.
Biomed Opt Express. 2016 Jan 21;7(2):616-28. doi: 10.1364/BOE.7.000616. eCollection 2016 Feb 1.
Diffuse reflectance spectroscopy (DRS) has been utilized to study biological tissues for a variety of applications. However, many DRS systems are not designed for handheld use and/or relatively expensive which limit the extensive clinical use of this technique. In this paper, we report a handheld, low-cost DRS system consisting of a light source, optical switch, and a spectrometer, that can precisely quantify the optical properties of tissue samples in the clinical setting. The handheld DRS system was employed to determine the skin chromophore concentrations, absorption and scattering properties of 11 patients with psoriasis. The measurement results were compared to the clinical severity of psoriasis as evaluated by dermatologist using PASI (Psoriasis Area and Severity Index) scores. Our statistical analyses indicated that the handheld DRS system could be a useful non-invasive tool for objective evaluation of the severity of psoriasis. It is expected that the handheld system can be used for the objective evaluation and monitoring of various skin diseases such as keloid and psoriasis.
漫反射光谱法（DRS）已被用于研究生物组织，以用于各种应用。然而，许多DRS系统并非为手持式使用而设计，和/或相对昂贵，这限制了该技术的广泛临床应用。在本文中，我们报告了一种手持式、低成本的DRS系统，该系统由光源、光学开关和光谱仪组成，能够在临床环境中精确量化组织样本的光学特性。该手持式DRS系统用于测定11例银屑病患者的皮肤发色团浓度、吸收和散射特性。将测量结果与皮肤科医生使用银屑病面积和严重程度指数（PASI）评分评估的银屑病临床严重程度进行比较。我们的统计分析表明，手持式DRS系统可能是一种用于客观评估银屑病严重程度的有用的非侵入性工具。预计该手持式系统可用于客观评估和监测各种皮肤疾病，如瘢痕疙瘩和银屑病。
