Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
Trends Biotechnol. 2011 May;29(5):213-21. doi: 10.1016/j.tibtech.2011.01.006. Epub 2011 Feb 15.
Imaging modalities play an important role in the clinical management of cancer, including screening, diagnosis, treatment planning and therapy monitoring. Owing to increased research efforts during the past two decades, photoacoustic imaging (a non-ionizing, noninvasive technique capable of visualizing optical absorption properties of tissue at reasonable depth, with the spatial resolution of ultrasound) has emerged. Ultrasound-guided photoacoustics is noted for its ability to provide in vivo morphological and functional information about the tumor within the surrounding tissue. With the recent advent of targeted contrast agents, photoacoustics is now also capable of in vivo molecular imaging, thus facilitating further molecular and cellular characterization of cancer. This review examines the role of photoacoustics and photoacoustic-augmented imaging techniques in comprehensive cancer detection, diagnosis and treatment guidance.
成像方式在癌症的临床管理中起着重要作用，包括筛查、诊断、治疗计划和治疗监测。由于在过去二十年中加大了研究力度，光声成象（一种能够在合理深度可视化组织的光吸收特性的非电离、非侵入性技术，具有超声的空间分辨率）已经出现。超声引导光声成象因其能够提供肿瘤在周围组织内的体内形态和功能信息而受到关注。随着最近靶向对比剂的出现，光声成象现在也能够进行体内分子成象，从而促进对癌症的进一步分子和细胞特征分析。本综述探讨了光声成象和光声增强成象技术在癌症综合检测、诊断和治疗指导中的作用。
