St Thomas' Hospital and King's College, London, UK.
J Clin Pathol. 2011 May;64(5):380-6. doi: 10.1136/jcp.2010.080838. Epub 2011 Feb 15.
Avoiding errors in the histological interpretation of bone marrow trephine biopsy specimens requires an unprecedented degree of collaboration between histopathologists, haematologists, specimen requesters, specimen takers, laboratory technical staff and other scientific staff. A specimen of good quality, with full, relevant clinical information is the essential starting point. This must then be processed optimally and investigated appropriately, involving immunophenotyping and molecular testing when needed. A wide range of pathologies may involve bone marrow haemopoietic and stromal components, and a systematic approach to analysing each of the components in turn is required to avoid overlooking abnormalities; correlation with bone marrow cells aspirated in parallel is particularly important. Final interpretation should be a synthesis of the histological findings with information from such haematological and other investigations, interpreted with due regard to clinical context.
避免在骨髓活检组织学解释中出现错误需要病理学家、血液学家、标本申请医生、标本采集者、实验室技术人员和其他科学人员之间前所未有的合作。高质量的标本，附有完整的、相关的临床信息，是必不可少的起点。然后必须对其进行最佳处理并进行适当的检查，必要时包括免疫表型和分子检测。广泛的病理学可能涉及骨髓造血和基质成分，需要系统地依次分析每个成分，以避免遗漏异常；与并行抽吸的骨髓细胞进行相关性分析尤为重要。最终的解释应该是组织学发现与血液学和其他检查信息的综合，在解释时应充分考虑临床背景。
